Congress.gov119th Congress

S. 545

Combating Illicit Xylazine Act

Introduced Feb 12, 2025Latest action Apr 15, 2026Crime and Law Enforcement

Plain-English summary

Combating Illicit Xylazine Act This bill regulates xylazine under the Controlled Substances Act (CSA). Xylazine, also known as tranq , is a nonopioid sedative and pain reliever that is approved for use in animals. Recently, the Drug Enforcement Administration (DEA) has reported an increase in trafficking of fentanyl mixed with xylazine. This bill adds xylazine, including its salts, isomers, and salts of isomers, to schedule III of the CSA.

Deterministically condensed from the official CRS summary; verify details in the official record.

People and recorded decisions

Sponsors, Cosponsors & House Votes

Ruben Gallego

Cosponsor · Democratic · AZ

Rick Sen Scott

Cosponsor · Republican · FL

Maria Cantwell

Cosponsor · Democratic · WA

Cynthia M. Lummis

Cosponsor · Republican · WY

Richard Blumenthal

Cosponsor · Democratic · CT

Timothy Michael Kaine

Cosponsor · Democratic · VA

Richard J. Durbin

Cosponsor · Democratic · IL

Kirsten E. Gillibrand

Cosponsor · Democratic · NY

Jeffrey Alan Merkley

Cosponsor · Democratic · OR

Rafael Edward Ted Cruz

Cosponsor · Republican · TX

Roger Sen. Wicker

Cosponsor · Republican · MS

Ashley Moody

Cosponsor · Republican · FL

Katie Boyd Britt

Cosponsor · Republican · AL

Dave Mccormick

Cosponsor · Republican · PA

Thom R Sen Tillis

Cosponsor · Republican · NC

Charles E Grassley

Cosponsor · Republican · IA

Ted Budd

Cosponsor · Republican · NC

Todd Christopher Young

Cosponsor · Republican · IN

KELLY, MARK

Cosponsor · Democratic · AZ

Ben Ray Luján

Cosponsor · Democratic · NM

John Karl Fetterman

Cosponsor · Democratic · PA

Cindy Hyde-Smith

Cosponsor · Republican · MS

Michael F. Bennet

Cosponsor · Democratic · CO

James Conley Justice II

Cosponsor · Republican · WV

Michael D Crapo

Cosponsor · Republican · ID

Shelley Moore Capito

Cosponsor · Republican · WV

James Lankford

Cosponsor · Republican · OK

James E Mr. Risch

Cosponsor · Other · ID

Catherine Cortez Masto

Sponsor · Democratic · NV

Angus S. King Jr.

Cosponsor · Independent · ME

Marsha Blackburn

Cosponsor · Republican · TN

Amy Klobuchar

Cosponsor · Other · MN

Margaret Wood Hassan

Cosponsor · Democratic · NH

Jacky Rosen

Cosponsor · Democratic · NV

John Sen Cornyn

Cosponsor · Republican · TX

Jeanne Shaheen

Cosponsor · Democratic · NH

No linked House roll-call vote is available yet. Senate votes are not currently synchronized.

Official Subjects

Crime and Law EnforcementConsumer affairsU.S. Sentencing CommissionVeterinary medicine and animal diseasesCriminal procedure and sentencingDrug safety, medical device, and laboratory regulationManufacturingDrug trafficking and controlled substancesCongressional oversightLicensing and registrations

Action Timeline

Apr 15, 2026

Placed on Senate Legislative Calendar under General Orders. Calendar No. 372.

Apr 15, 2026

Committee on the Judiciary. Reported by Senator Grassley with an amendment in the nature of a substitute. Without written report.

Mar 26, 2026

Committee on the Judiciary. Ordered to be reported with an amendment in the nature of a substitute favorably.

Feb 12, 2025

Read twice and referred to the Committee on the Judiciary.

Feb 12, 2025

Introduced in Senate

Sources & text

Official Congress.gov record ↗Reported to Senate ↗Reported to Senate ↗Reported to Senate ↗Introduced in Senate ↗

Congress.gov data last updated Sep 2, 2026. Automated summaries preserve a source version and generation timestamp; human edits are explicitly recorded.